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    Praise for Total Holographic Characterization:

    "THC shows a significant superiority to FI and RMM in detecting heterogenous protein aggregates which often appear as transparent and porous particles."

    FROM: The Journal of Pharmaceutical Sciences, The Strengths of Total Holographic Video Microscopy in Detecting Sub-Visible Protein Particles in Biopharmaceuticals: A Comparison to Flow Imaging and Resonant Mass Measurement

    Harri Rahn*, Merve Oeztuerk, Nikolai Hentze, Friederike Junge, Markus Hollmann

    AbbVie Deutschland GmbH & Co. KG, Knollstraße, Ludwigshafen 67061, Germany

    "In this study, three techniques, including Raman microscope, BMI and THC, were screened to monitor the formation of FFA particles in placebo solution. The results indicated THC is the most suitable one, featuring high sensitivity, minimal interruption to samples and low interference from formulation matrices."

    FROM: European Journal of Pharmaceutics and Biopharmaceutics, Screening Techniques for Monitoring the Sub-visible Particle Formation of Free Fatty Acids in Biopharmaceuticals

    Wei Chen, Denis Klemm, Kathrin Gregoritza, Ravuri Satya Krishna Kishore, Jan Olaf Stracke, Christine Wurth, Cosimo Pinto, Nuria Sancho Oltra

    F. Hoffmann-La Roche AG, Grenzacherstrasse 124, 4070 Basel, Switzerland

    Spheryx, with its revolutionary technique Total Holographic Characterization®, delivers solutions that provide a new window into suspensions at the sub-visible level.

    Suspensions are a part of our daily lives from electronics, pharmaceuticals and industrial fluids to water quality, cosmetics, chemicals and petroleum products. All of these products must be analyzed throughout the development, manufacturing and quality assurance processes to ensure product quality and consistency.

    Spheryx provides capabilities, never before possible, to develop and monitor products and provide improved information and control. The results will be better, more effective products, less waste, and increased efficiency, producing cost savings and improved market share.

    Semiconductor Manufacturing
    Biologic Pharmaceuticals
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    Water Quality
    Consumer Products

    Upcoming Appearances

    ACS Colloid and Surface Science Symposium

    June 23-26, 2024
    Seattle, WA

    Learn more here:

    2024 Colorado Protein Stability Conference

    August 5-8, 2024
    Breckinridge, CO

    Learn more here:

    Next Generation Analytical Methods

    August 21-22, 2024
    Boston, MA

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    2024 Military Health System Research Symposium

    August 26-29, 2024
    Kissimmee, FL

    Learn more here:

    AAPS PharmSci 360 Conference

    October 20-23, 2024
    Salt Lake City UT

    Learn more here:

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